Immunomodulatory activity of vardenafil on induced lung inflammation in cystic fibrosis mice
نویسندگان
چکیده
منابع مشابه
Targeting Lung Inflammation in Cystic Fibrosis
Cystic fibrosis (CF) is an autosomal recessive disease found mostly in the Caucasian population; a major complication of CF that often leads to mortality is lung inflammation. Playing a key role in the inflammation, as demonstrated by several studies, is the continuous recruitment of neutrophils to the lung [1-3]. Despite these millions of activated neutrophils, CF patients cannot adequately de...
متن کاملBacterial activity in cystic fibrosis lung infections
BACKGROUND Chronic lung infections are the primary cause of morbidity and mortality in Cystic Fibrosis (CF) patients. Recent molecular biological based studies have identified a surprisingly wide range of hitherto unreported bacterial species in the lungs of CF patients. The aim of this study was to determine whether the species present were active and, as such, worthy of further investigation ...
متن کاملEffect of thalidomide on the alveolar epithelial cells in the lung fibrosis induced by bleomycin in mice
Introduction: Idiopathic pulmonary fibrosis (IPF) is a relentlessly progressive and usually fatal lung disease of unknown etiology for which no effective treatments currently exist. In the adults type I and II pneumocytes, forms Components of the alveolar epithelial cells. In this study, we investigated the effect of thalidomide on the alveolar epithelial cells (type I and II pneumocytes) in ...
متن کاملInflammation in Cystic Fibrosis
Mediators of Inflammation 5, 121-143 (1996) Inflammation in Cystic Fibrosis International Symposium
متن کاملEarly airway infection, inflammation, and lung function in cystic fibrosis.
AIMS To determine the relation between lower airway infection and inflammation, respiratory symptoms, and lung function in infants and young children with cystic fibrosis (CF). METHODS A prospective study of children with CF aged younger than 3 years, diagnosed by a newborn screening programme. All were clinically stable and had testing as outpatients. Subjects underwent bronchial lavage (BL)...
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ژورنال
عنوان ژورنال: Journal of Cystic Fibrosis
سال: 2012
ISSN: 1569-1993
DOI: 10.1016/j.jcf.2012.03.003